Lolita Matiashova

Conference 2022 Pre-recorded Presentation

 

Video title

Inflammation in Hypertensive Patients on Stable Therapy with Non-dipper and Dipper Status

 

Authors and Affiliations

Lolita Matiashova1

1. L T Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine

 

Abstract

Background

Hypertension has a negative effect on the cardiovascular system, but the data are limited about the connection between non-dipper hypertension and inflammation.The aim of this work was to study the effects of dipper and non-dipper hypertension on inflammatory factors.

Methods

The cross-sectional study included 125 hypertensive patients (54 men) with median age 56,5 (45.00 ÷ 63.70) years old and 41 normotensive subjects with median age 52 (41 ÷ 63) years old. All hypertensive patients had been on stable antihypertensive therapy during the last three months and had target blood pressure at the moment of inclusion to the study. Ambulatory blood pressure monitoring was done to all patients with Heaco ABPM50 monitoring. Fasting glucose (FG), blood lipids, creatinine, uric acid, high sensitive C-reactive protein (hCRP) and interleukin 1 beta (IL-1B) were measured. Physical activity was assessed using the International Physical Activity Questionnaire. Data were analyzed with SPSS IBM 19.0.

Results

The mean of day and night systolic and diastolic blood pressure was 132.9∓17.3/ 78.9∓11.7 and 119.1∓19.7/ 68.9∓11.0 mm Hg, respectively. According to their night blood pressure, the patients were divided into dipper (n=72) and non-dipper (n=53). The mean of hCRP in dipper patients was 9.1 ∓8.2 and non-dipper 10.8∓6.5 mg/L (p=0.01). The mean of IL-1B in dipper patients was 2.4∓0.6 non-dipper2.5∓0.7 pg/mL (p>0.05).

Conclusions

Non-dipper hypertension could be an additional risk factor of vascular inflammation, future studies are needed.