Tarun Kumar Suvvari

Conference 2023 Presentation

Project title

Prevalence and Risk Factors Associated with Chronic Kidney Disease Among Type-2 Diabetes Mellitus Patients

Authors and Affiliations

Tarun Kumar Suvvari 1, Dr. Chandra Shekar Kali 1

1.Department of Medicine, Rangaraya Medical College, Kakinada, India

Abstract

Background

Globally, diabetes mellitus is one of the major causes of increased morbidity. One of the key complications of T2D is chronic kidney disease (CKD). Current evidence demonstrates that people with type 2 diabetes (T2D) are at a higher risk of developing chronic kidney disease (CKD) with greater morbidity and mortality. So, we aimed to find out the prevalence of CKD among T2DM patients and evaluate the correlation between age, duration of diabetes, HbA1c, and UACR with eGFR among T2DM patients.

Methods

An observational cross-sectional study was conducted for 2 months. The clinical data that collected was estimated glomerular filtration rate (eGFR), serum creatinine, urinary albumin creatinine ratio (UACR), and HbA1c levels. Descriptive statistics were used, and the Chi-square test was used to determine the role of socio-demographic characteristics on questions. Spearman rank correlation was used to determine the correlation between eGFR and various parameters.

Results

A total of 96 patients were included in the study. 65% of the study participants were sedentary and 35% were physically active. 41 (42.7%) were obese and 21 (21.9%) were overweight. The mean Duration of diabetes is 5.62 + 4.68 years. The mean estimated glomerular filtration rate (eGFR) is 74.33 + 31.01 mL/min/1.73m2. The Prevalence of CKD is 35.4%. 21.8% belongs to G3a category and 8.3% belongs to G3b category. Spearman’s correlation coefficient was used to we found negative correlation between eGFR and age, duration of diabetes, HbA1c and UACR.

Conclusions

In conclusion, nearly 1/3rd of study participants reported CKD. Our study provides consistent and recent clinical data showing an inverse association of eGFR with age and duration of diabetes. This study highlights that age and duration of diabetes are key parameters associated with declining renal functions in people with T2D in India. Intensive screening for diabetic patients is recommended for early detection of CKD. We also recommend studying the effect of anti-diabetic and anti-hypertensive medications on the rate of renal function deterioration, as well as evaluating the mortality rate and progression to end stage renal disease (ESRD) and dialysis in each eGFR category.