Madinat Hassan

Conference 2023 Presentation

Project title

Hypolipidemic effect of ethanol extract of Ipomoea asarifolium on Triton X-100 induced hyperlipidemia in rats

Authors and Affiliations

Madinat Hassan1, Sunday Zeal Bala2, Muhibat Bolanle Komolafe1, Jemila Saleh1, Shehu Amina Bature1, Usman Ameena Muhammad3, and Yusuf Alhassan3

1 Biology Unit, Airforce Institute of Technology, Kaduna State, Nigeria
2 Biochemistry Department, Bayero University Kano, Kano State, Nigeria
3 Biochemistry Department, Kaduna State University, Kaduna State, Nigeria

Abstract

Background

Hyperlipidemia is a disorder characterized by an increase in blood lipoprotein or cholesterol levels. It is a major cause of cardiovascular disease causing mortality and morbidity globally. In many parts of Nigeria, particularly the North, folk medicine has been used to manage hyperlipidemia, and one of the medicinal plants used for the treatment is Ipomoea asarifolium whole plant. This study aims to uphold the use of this plant in traditional therapeutic practice

Methods

The phytochemical constituent of ethanol extract of Ipomoea asarifolium (EEIA) was estimated in the form of Total flavonoid and Total phenol content after which the animals were subsequently divided into six groups. The antihyperlipidemic effect of EEIA was evaluated in high-fat diet/Triton X-100-induced hyperlipidemia in rats for a period of seven days.

Results

The EEIA exhibited a strong hypolipidemic (75%) activity at a dose of 100 and 200 mg/kg respectively. The effect of the EEIA was found to be dose-dependent at the aforementioned dosage. The positive control group administered atorvastatin, completely exhibited hypolipidemic activity in the rats

Conclusions

It is evident from this study that EEIA constitutes active phytochemicals that might have triggered the hypolipidemic activity observed