Dr. Anastasia Nijnik Canada Loss of MYSM1 deubiquitinase catalytic activity protects against MYC-driven lymphoma Dania Shaban 1,2,#, Viktoria Plackoska 1,2,#, Yue Liang 1,2, Nay Najm 1,2, Francis Robert 3,4, Sidong Huang 3,4,5, Anastasia Nijnik 1,2* 1 Department of Physiology, McGill University, Montreal, QC, Canada 2 McGill University Research Centre on Complex Traits, McGill University, QC, [...]

Felipe Pinto Brazil Deletion of natterin impairs NLRP3 inflammasome activation and host defense against Salmonella typhimurium in zebrafish Felipe Justiniano Pinto1; Darlan Gusso1; Jefferson Thiago Gonçalves Bernardo1; Aline Ingrid Andrade-Barros1; Carlos DeOcesano-Pereira2; Monica Lopes-Ferreira1; Carla Lima1 1. Plataforma Zebrafish of the Laboratory of Applied Toxinology (CeTICs/FAPESP), Instituto Butantan, São Paulo, Brasil 2. Centre of Excellence [...]

Dr. Fernando Flores-Guzman U.S.A. Bone marrow dormant tumor cells maintain reactive memory CD8 T cells Flores-Guzman Fernando1,5, Federico-Guerrero Alfonso2, Morales-Ramirez Claudia A3, Carrasco-Ramirez Liliana4, Umansky Viktor5, Carrasco-Ramirez Elba6 1. Surgery Department, University of Colorado, Denver Colorado, USA 2. Microbiology Department, School of Medicine, UNAM, Mexico City 3. General Hospital Dr. Enrique Cabrera, Mexico City 4. [...]

Dr. Valentina Venzin France CD4+ T cells license Kupffer cells to produce IL-27 and reverse CD8+ T cell dysfunction induced by hepatocellular priming Valentina Venzin1,2, Cristian G. Beccaria1,2, Chiara Perucchini1,2, Pietro Delfino1, Elisa B. Bono1, Leonardo Giustini1, Federica Moalli1,3, Marta Grillo1,2, Valeria Fumagalli1,2, Chiara Laura1,2,4, Pietro Di Lucia1,2, Katharina Reinhard5, Jutta Petschenka6, Tana Annmarie Omokoko5, [...]

Dr. Yan Gao Canada FAM72A potentiates APOBEC3B-driven cytidine deamination and mutagenic repair to promote colorectal tumorigenesis Yan Gao 1, Mohammad Khakpoor Koosheh1, Bhupesh Thakur 1, Maribel Berru1, Alberto Martin 1 1 Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada Abstract Background APOBEC3B (A3B) promotes cytidine-to-uracil (C‚ÜíU) deamination and generates clustered mutations characteristic [...]

Emmanuel Amewu Sghana The association between submicroscopic Plasmodium infections and gut microbiota among children in Ahanta West, Ghana Emmanuel K. A. Amewu1, Rosemond Enam Mawuenyega2, Bismark Koduah2, Alexander Kwarteng2,3, Amma A. Larbi2 1. Department of Molecular Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana 2. Department of Biochemistry [...]

Christos Tsagkaris Switzerland Safeguarding cancer care during crises: Lessons from the Institute of Cancer and Crisis Christos Tsagkaris1, Jemma Arakelyan2 Abstract Background Crises challenge health systems and highlight the essential role of civil society in maintaining care beyond formal structures. While emergency responses often prioritise trauma, infectious disease, and acute care, the convergence of [...]

Emily Siniscalco U.S.A. Mucosal immunization induces linked local and systemic humoral responses Emily R. Siniscalco1,2; Hailong Meng3; Gisela Gabernet3; Gaspar. A. Pacheco4,5,6,7; Shahab Saghaei4,5,6,7; Sydney I. Ramirez8,9; L. Benjamin Hills9,10; Farhoud Faraji9,11; Shuting Chen1; Xiangyun Yin1,12; Christine Dien1,3,13,19; Laura R. Hoyt1; Elise G. Liu13; Abel Barrett14; Neima Briggs15; Adam Williams2,16; Vipul Shukla2,17; Shane Crotty8,9, Duane [...]

Javier Orozco-Cordoba Mexico Trim33 regulates TH9 differentiation and in vivo function. Javier Orozco-Cordoba1, Eugenio Contreras-Castillo1, Ofelia Muñoz-Paleta1, Daniel Zambrano-Romero1, Jose Luis Ramos-Balderas1, Paula Licona-Limon1 1. Instituto de Fisiologia Celular, UNAM. Abstract Background The TGF-β signaling pathway has been extensively studied in CD4+ T cells, particularly in TH17, Treg, and, more recently in TH9 cells, characterized [...]