Anwar Rovik

Indonesia

Multitarget Chemopreventive Potential of Mimosa pudica (Linn.) in Luminal-type Breast Cancer: A Bibliometric and Network Pharmacology Analysis

Anwar Rovik1,2, Laelatul Afifah1, Vania Uly Andyra1

1Graduate Program in Biotechnology, The Graduate School of Universitas Gadjah Mada, Yogyakarta, Indonesia
2Cancer Chemoprevention Research Center (CCRC), Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia

Abstract

Background

The rising prevalence of breast cancer, combined with the limitations of current treatments, calls for the investigation of new therapeutic strategies. This study used a network pharmacology approach to understand the anticancer potential of M. pudica against luminal-type breast cancer.

Methods

Bioactive compounds from M. pudica were analyzed in silico to evaluate their drug-likeness and predict possible protein targets. The protein-protein interaction (PPI) network was constructed and visualized using Cytoscape. Molecular docking simulations assessed the binding affinity of selected ligands, including apigenin, galangin, kaempferol, diosmetin, and chrysin, to proteins involved in cell cycle regulation.

Results

The analysis showed that M. pudica contains various bioactive compounds with potential anticancer properties. The target proteins identified are involved in essential cellular processes related to cancer progression, such as cell cycle regulation, DNA metabolism, growth factor signaling, angiogenesis, metastasis, and invasion. Notably, the ligands demonstrated strong binding affinities to AURKA and CDK1, key regulators of the cell cycle, with binding energies between -7.6 and -8.9 kcal/mol.

Conclusions

These results provide important mechanistic insights into the anticancer effects of M. pudica and highlight its potential as a promising source of therapeutic agents for treating luminal-type breast cancer.