Noah Olabode Olaleke

Conference 2023 Presentation

Project title

Thrombocytopenia in HIV positive patients in Ilorin North-Central Local Government, Kwara State, Nigeria

Authors and Affiliations

Olaleke Noah Olabode1, Hezekiah O. Idowu2, Okesanya Olalekan John3, Ayodeji A. Faniyi1, Mary I. Omoge4, Omosigho Omoruyi Pius5.

1. Obafemi Awolowo University Teaching Hospitals Complex Ile-Ife, Osun-State, Nigeria.
2. University College Hospital Ibadan, Oyo-State, Nigeria.
3. Department of Medical Laboratory Science, Neuropsychiatric Hospital Aro Abeokuta, Ogun-State, Nigeria.
4. University of Benin Teaching Hospital Benin, Edo-State, Nigeria.
5. Edo State University Uzaire, Edo-State, Nigeria.

Abstract

Background

Acquired immunodeficiency syndrome (AIDS) is a systemic disorder caused by human immunodeficiency virus (HIV) and is characterized by severe impairment and progressive damage of both cellular and humoral immune responses which altered hematopoiesis and affects all three cell lines and consequently, these patients may suffer from anemia, leucopenia, thrombocytopenia, or any combination of these three. This study aimed to determine the prevalence of thrombocytopenia in HIV positive patients in Ilorin North Central Kwara State, Nigeria.

Methods

A cross-sectional study and experimental survey of Platelet counts was carried out on 200 blood samples collected from both HIV positive and negative individuals using Auto-Hematology analyser. Data obtained were statistical analysis using SPSS 23.0 to determine probability at 5% level of significance.

Results

Results obtained showed no significant differences(p>0.05) in the prevalence of thrombocytopenia of HIV positive patients regarding their age groups, gender, marital status, education status, duration of infection, residence and occupation and in HIV negative control subjects. The comparison of platelet counts between HIV positive patients and control group, thrombocytopenia among HIV positive patients of different age groups and different occupation also revealed no significant difference (p>0.05). However, the study showed that 6(3.75%) had thrombocytopenia among HIV positive patient based on the viral load.

Conclusions

This study revealed that platelet counts in HIV positive patients reduces as the infection increases in stages and number of years, the usage of HAART help decrease the prevalence of thrombocytopenia and its subsequent complications. It was recommended that HIV positive be advices on the need the regular use of HAART drugs prescribed as it was seen to improve platelet counts and reduce the risk of platelet associated clinical challenges.