Sojit Tomo

Conference 2023 Presentation

Project title

Increased Type IV Lipoprotein phenotypes in Indian patients based on the new classification when compared with western population.

Authors and Affiliations

Sojit Tomo 1 , Shrimanjunath Sankanagoudar 1* , Prem Prakash Sharma 2 , Mithu Banerjee 1 , Praveen Sharma 1

1.Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, India. 2.Department of Statistics, All India Institute of Medical Sciences, Jodhpur, India.

Abstract

Background

The lipoprotein phenotyping is performed using density gradient ultracentrifugation or agarose gel electrophoresis, which are cost-intensive methodologies. As a result, lipoprotein phenotyping is not available routinely in clinical laboratories. Further there is a lack of data on the prevalence of different lipoprotein phenotypes in India. Thus, it has garnered considerable attention when Sampson et al. (2021) have put forward their new lipoprotein phenotyping method using only those parameters that are available in the standard lipid panel.

Methods

The retrospective study was carried out after obtaining approval from the Institutional Ethics Committee. We retracted the lipid profile data from the clinical laboratory database, from January 2020 to May 2021. All parameters were estimated in Beckman AU 680 clinical chemistry analyser after calibration and quality control. The new lipoprotein phenotyping method, proposed by Sampson et al., were used to classify the subjects into different categories and was compared with that of western population (Sampson et al., 2021).

Results

A total of 10783 patients’ data were included in the study after removing the duplicates. In our study, we observed 46.51% of patients to be Normolipidemic, Subtype: Moderate. When compared with western population, we observed a substantial increase in the prevalence of Normolipidemic, Subtype: Low in Indian patients (14.1% vs 21.98%). In addition, we also observed a substantial increase in Type IVa ( 4.2% vs 9.45%) and Type IVb ( 8.3% vs 15.87%) in Indian patients when compared with western population.

Conclusions

Our study describes the prevalence of lipoprotein phenotypes in Indian patients based on the new classification by Sampson et al. (2021). Our study highlights the increase in prevalence of Normolipidemic, Subtype: Low, Type IVa and Type IVb in Indian patients. The information, regarding the increased prevalence of various subtype, will guide in formulating treatment protocols for dyslipidemia in Indian population.