Conference 2021 Poster Presentation

 

Project title

Effect of Intermittent Fasting on Health Status in Patients with Diabetes Mellitus, Cardiovascular Diseases and Metabolic Syndrome: Systematic Review

 

Authors and Affiliations

Lolita Matiashova1, Christos Tsagkaris2, Ganna Isayeva1

1. “L.T.Malaya Therapy National Institute of the NAMS of Ukraine” Department of Comprehensive Risk Reduction for Chronic Non-Communicable Diseases, Kharkiv, Ukraine
2. University of Crete, Faculty of Medicine, Heraklion, Greece

 

Abstract

Background

Correction of eating behavior is the cornerstone of prevention, especially cardiovascular disease (CVD). The most common methods of correction are calorie restriction (CR) and interval fasting (IF). Both methods have been shown to be effective in weight loss, but IF has the advantage over CR in that it does not require constant strict adherence to dietary restrictions. Many studies indicate that IF also has positive effects on health and can be used for prevention in medical practice. There is currently no detailed information on the effect of IF on CVD risk factors in patients with diabetes, obesity and cardiovascular disease. The purpose of this study is to analyze and summarize the available data on the effects of IF on the health status of patients with type 2 diabetes mellitus (DM2), cardiovascular and metabolic diseases, over 18 years old.

Methods

Systematic review was done. Electronic databases (MEDLINE, Web of Science, Scopus and Google Scholar) have been searched for the last 5 years (2015-2020) in English, Ukrainian, Russian languages. Tools used in the analysis were the PRISMA protocol, JADAD scale, ROBINS-I and RoB 2 tools.

Results

In our systematic review 28 original articles were included. All studies had a low risk of ROBINS-I and RoB 2 tool and from 2 to 6 points on the JADAD scale. A statistically significant decrease was found: in 14 studies of weight, in 7 studies of blood pressure, in 3 studies of low-density lipoproteins and triglycerides, in 2 studies of HbA1c, in 3 studies of fasting glucose. Other studies showed a decrease without statistical significance: HOMA index, total cholesterol, heart rate, apo-3, IL-6, TNF and adiponectin. One study showed increased in case of hypoglycemia in patients with T2D, which was controlled after correction of dose hypoglycemic treatment. Data on serious side effects and mortality were absent.

Conclusions

Thus, the data from our analysis indicate the safety of IF use in patients with diabetes mellitus, cardiovascular and metabolic diseases. And the effectiveness of IF in reducing the risk factors for cardiovascular disease. Further long-term studies are needed to investigate the effect of IF on mortality in patients with comorbid pathology.

 


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