Conference 2021 Poster Presentation

 

Project title

The Role of Hyaluronic Acid as Wound Dressing in Diabetic Ulcer

 

Authors and Affiliations

Abed Nego Okthara Sebayang1, Niko Azhari Hidayat2, Syahroni Ibnu3

1. Departement of Surgery, Medical Faculty of HKBP Nommensen Medan, Indonesia
2. Kaki Diabet Indonesia

 

Abstract

Background

Diabetes Mellitus (DM) is a chronic disease characterized by hyperglycemia and glucose intolerance. In people with DM complications can occur at all cellular levels and all anatomic levels. One of the complications is the occurrence of diabetic ulcers. Some of the adjuvant therapies used include: the use of granulocyte colony stimulating factors (GCSF), administration of growth factors (growth factor therapy) and bioengineered tissue, and hyperbaric oxygen therapy and most recently the use of hyaluronic acid which is a natural polymer in the management of diabetic ulcers.

Methods

The research method used is literature study by collecting various sources from both books and journals. The analysis technique used is descriptive analysis of the content analysis provided to describe in detail a particular message or text. Hyaluronic acid in the case of diabetic ulcers in helping tissue regeneration

Results

Hyaluronic Acid (HA) is a natural polysaccharide which is the main component of the extra cellular matrix of mammalian connective tissue. In the healing process of diabetic ulcers, HA functions to inhibit bacterial proliferation by stimulating the production of β-defensin 2 as a skin epithelial defense mechanism and acts as an anti-inflammatory. In addition, HA also functions to form myofibroblasts and granulation tissue deposition, reepithelialization and assist in fibroblast proliferation.

Conclusions

Diabetic ulcer is a condition in which tissue damage occurs due to high blood sugar levels in DM patients, causing vasculopathy. HA plays a role in all phases of wound healing so it is very effective in accelerating the formation of new tissue. in addition, HA also plays a role in reducing pain because it blocks opioid receptors.