Paolo Sassone-Corsi was the Director of the Center for Epigenetics and Metabolism, at the UCI School of Medicine. Paolo received his Ph.D. from the International Institute of Genetics and Biophysics, CNR, Naples, Italy, in 1979. He was a postdoctoral fellow with Dr. Pierre Chambon at the French National Centre for Scientific Research (CNRS) in Strasbourg, where he made the initial characterization of the transcriptional regulatory elements that became known as enhancers. Paolo was a leader in our understanding of how circadian rhythms control gene expression through epigenetic regulation. He is internationally known for his work in transcriptional regulatory circuits and in particular for discoveries that link metabolism with epigenetic mechanisms of generating and controlling circadian rhythms. Particularly, Paolo’s lab identified that NAD+ levels were circadian, and this rhythmicity ultimately controlled the activity of the sirtuins and histone acetylation.Dr. Sassone-Corsi was also the recipient of numerous honors and awards. Among these, he was an elected Fellow of the American Association for the Advancement of Science. International awards included the EMBO Gold Medal, the CNRS Silver Medal of France, and the Leonardo da Vinci Gold Medal of Italy.Paolo’s extraordinary energy and innovative approach to biology is reflected in his scientific legacy. Paolo has authored more than 420 peer-reviewed scientific papers and has mentored over 200 trainees. For those who knew Paolo well, his legacy is not only his science, but the memory of the exemplary man that had deep compassion for others, followed personal convictions, and saw the beauty and magic in life every day.