Amulya Etikala India Targeted Brain Delivery of Berberine Nanoemulsion: Preclinical Insights and Cognitive Rescue in Scopolamine-Induced Alzheimer’s Model Etikala Amulya*1, Mansi Negi1, Vivek Phatale1, Saurabh Srivastava1 1. Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, India Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder predominantly affecting the elderly. [...]
Abida Bhat India Epigenetic modulation of VEGF-A/VEGFR2 pathway in EOC/TME axis driving genetic upregulation and tumor plasticity. Abida bhat, Dil Afroze Advanced centre for human genetics (ACHG), Sher-i-kashmir institute of medical sciences ( SKIMS), Srinagar, Kashmir, India. Abstract Background Epithelial Ovarian Cancer (EOC), the most common ovarian cancer, presents challenges due to late diagnosis, histopathological [...]
Sahithya Varier Moldova Bioinformatic signatures predicting early Type 2 Diabetes Mellitus. Diya Uday1, Sahithya Madhusoodanan Varier2, Stela Vudu3 1. Nicolae Testemițanu State University of Medicine and Pharmacy, Chișinău, Republic of Moldova 2. Nicolae Testemițanu State University of Medicine and Pharmacy, Chișinău, Republic of Moldova 3. Department of Endocrinology, Nicolae Testemițanu State University of Medicine and [...]
Sara Munir Pakistan In-Silico Clinical Trials Powered by Mechanistic Digital Twins: Reducing Animal and Human Subject Exposure in Precision Oncology Sara Munir1 1. Department of Pharmacy,University of the Punjab,lahore,Pakistan Abstract Background Cancer drug development remains one of the most inefficient processes in medicine. More than nine out of ten candidate therapies fail between phase I [...]
Sheriffdeen Hammed Nigeria Identification of Novel DYRK1A Inhibitors as Treatment Options for Alzheimer’s Disease through Comprehensive In Silico approaches Ibrahim Akindeji Makinde1, Sheriffdeen Oladimeji Hammed2,3, Neeraj Kumar4, Najwa Ahmad Kuthi5, Haruna Isiyaku Umar3,6, Temitayo Abidat Hassan3,6, Idayat Oyinkansola Kehinde3, Ridwan Opeyemi Bello3,7, Abdullahi Tunde Aborode3,8, Tajudeen Ogundare Jimoh9, Al-Djazouli O Mahamat10, Ahmad Mohammad Salamatullah11 1 [...]
Sara ElSayed Reda Egypt Preconditioning of bone marrow mesenchymal stem cells with sodium hydrosulfide enhances their therapeutic potential in CIA rat model Sara M. El-Sayeda, Hanaa H. Ahmedb,c, Hadeer A. Aglanb,c, Mohamed M. Naguiba, Mohamed R. Mohameda* aBiochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt. bHormones Department, Medical Research and Clinical Studies Institute, [...]
Halima KHOLAIQ Morocco Human genetic and immunological determinants of SARS-CoV-2 infection Halima Kholaiq1, Jalila El Bakkouri1,2, Ahmed Aziz Bousfiha1,2,3 1. Laboratory of Clinical Immunology, Inflammation and Allergies (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco 2. Immunopathology-Immunotherapy-Immunomonitoring Laboratory, Faculty of Medicine, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco. 3. [...]
Adam Abdullahi United Kingdom Sero-genomic evidence for occult mpox exposure in healthy Nigerian adults Adam Abdullahi1 1. Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK Abstract Background BACKGROUND: The 2022 multi-country mpox outbreak, driven by Monkeypox virus (MPXV) Clade IIb, spread to over 100 countries, reigniting [...]
Emmanuel Ndezure Ghana In Vitro Antimicrobial Activities of Vernonia amygdalina and Senna siamea Against ESBL-Producing and Non-ESBL Bacteria Sumaila Mohammed1, Emmanuel Ndezure1*, Joseph Agyin1, Francisca Dery1, Ekua Amoah1, Kwadwo Boampong1 1. Kwame Nkrumah University of Science and Technology, Department of Theoretical and Applied Biology, Kumasi, Ghana Abstract Background Antimicrobial resistance (AMR), particularly in extended-spectrum beta-lactamase [...]
Tanya Jindal India "In Silico Discovery of phytochemicals Inhibiting Bacterial Urocanate Reductase to Prevent Imidazole Propionate-Mediated Insulin Resistance in T2D" Tanya Jindal1, Rohit Bansal1, Preeti Kumari1, Archana Bhatnagar1 1. Department of Biochemistry, Panjab University, Chandigarh, India. Abstract Background Type 2 Diabetes Mellitus (T2DM) is a complex metabolic disorder primarily associated with insulin resistance and impaired [...]