The National Institute of Immunology (NII) is committed to advanced research addressing the basic mechanisms involved in body's defence to identify modalities for manipulation of the immune system to provide protection against diseases and understand mechanisms that can be used to target disease processes for intervention.

The institute’s research thrust areas under immunology and related disciplines cluster in four main themes, namely, infection and immunity, molecular design, gene regulation and reproduction and development, where cutting edge research in modern biology is being carried out.

The institute has plans to embark upon integrated research in human disease biology, where complex questions of susceptibility to and spread of diseases in field conditions are intended to be addressed using systems approaches. These research efforts will create an internationally competitive intellectual knowledge base as a sustainable source of innovative futuristic modalities of potential use in health care.